If you want a powerful crash course on why and how MIT is developing groundbreaking new therapies to treat endometriosis, you’ll want to watch this TEDx talk. In it, CGR Director Linda Griffith discusses how MIT researchers and others are “deconstructing and reconstructing the patient” as a way to develop new therapies.
About 10 percent of women have endometriosis, yet molecular subtypes and non-hormonal therapies have yet to be defined, leaving tens of millions of women around the world suffering. Griffith explains how at MIT, scientists in Biological Engineering are working with surgeons around the world to define molecular subtypes related to immune and invasion networks using a combination of experimental and machine learning approaches. Patients are then reconstructed from tissue biopsies, to test the mechanistic hypotheses about new non-hormonal therapies.